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The infection of 2019-nCoV can lead to overexpression of inflammatory factors, triggering cytokine storm and causing serious damage to the body. Glucocorticoids have anti-inflammatory properties and may be an effective treatment option. The use and dosage of glucocorticoids in coronavirus disease 2019 (COVID-19) remains controversial. This article reviews the theoretical basis, clinical evidence, debates and specific measures of glucocorticoids in the treatment of COVID-19, to provide reference for rational application of glucocorticoids in the future.
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Objective To analyze the registration and treatment outcomes of pulmonary tuberculosis (TB) between local and floating population in Panyu district in Guangzhou and provide equalization of basic public health services strategies to the prevention of TB.Methods According to the data from China Disease Prevention Information System of Panyu district, the patients between 2013 and 2015 were used for statistical analysis.The differences of treatment outcomes between local and floating TB patients were compared and analyzed by Chi-square test.Results There were 3,047 registered patients in 2013-2015 in Panyu district, the annual average TB registration rate was 68.13/100 000.1 476 of them were smear negative TB (48.44%);1421 new smear positive TB (46.64%);150 re-treated smear positive TB (4.92%).Among these patients, 2 202 cases were local pulmonary (72.27%), and 845 floating pulmonary (27.73%).There were statistical differences in the cure rate of new and re-treated patients (P0.05).Conclusion Local and floating TB patients receive the same health service under the full process monitoring Panyu.It shows the equal basic public health services policy has come out with preliminary results.
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Objective To analyze the effect of Evidence-based Care on the complication rate and comfort in patients with coronary heart disease after intervention therapy, and to provide reference for clinical care. Methods One hundred and twenty-two patients with interventional treatment of coronary heart disease in hospital from May 2013 to April 2015 were selected, patients were divided into control group (61 cases) and intervention group (61 cases) according to the care methods. Control group patients were given careful routine care, Intervention group patients were given Evidence-based Care, the complication rate and comfort of the two groups were compared. Results The incidence of postoperative complications in the intervention group (11.5%) was significantly lower than the control group (76.6%),P<0.05. The intervention group after 6h (61.5 ± 5.3), 12h (70.2 ± 4.5), 24h (87.5 ± 3.5) comfort were significantly higher than control group 6h (52.6 ± 6.8), 12h (61.2 ± 5.3), 24h (73.5 ± 4.2), P<0.05. The incidence of bad mood of intervention group were significantly lower than the control group, P<0.05. The intervention group patient care satisfaction (96.7%) was significantly higher than control group (86.9 %), P<0.05. Conclusion Evidence-based nursing for the patients with coronary heart disease undergoing PCI can greatly decrease vascular complications and improve comfort value.
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ObjectiveTo study the expression of EZH2 gene in cervical squamous carcinoma and its clinicopathologic significance. MethodsThe expression of EZH2 mRNA was detected in 21 samples of normal cervical tissue, 27 samples of CIN tissue and 48 samples of cervical squamous carcinoma tissue by RT-PCR. And the relationship between EZH2 expression and the clinical pathological characteristic was analyzed. ResultsThe level of EZH2 mRNA in cervical squamous carcinoma tissues(1.67±0.01)were significantly higher than that in the normal cervical tissues (0) and CIN tissues (0.36±0.02) (P ＜ 0.01).There was no correlation between EZH2 and ages (P ＞ 0.05), while the expression of EZH2 was highly correlated with histologic stage,clinical stage,muscular invasion depth and lymph node metastasis of cervical squamous carcinoma (P ＜ 0.01).ConclusionThe over-expression of the EZH2mRNA may play an important role in the pathogenesis and progression of cervical squamous carcinoma,suggesting that EZH2 might be a new biomarker for diagnosing cervical squamous carcinoma.
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Objective To investigate the risk factors for nosocomial bacteremia and decrease the prevalence of nosocomial bacteremia.Methods We collected the data of bacteremia patients in our hospital from January,2006 to December,2009.According to the criterion of nosocomial infection,the patients were divided into nosocomial bacteremia group (83) and community-onset bacteremia group (119).The influence of a series of variables on the development on both types of bacteremia was analyzed by Student＇s t test and x2 test.The risk factors were performed using multivariate logistic regression.Results Compared to that of community-onset bacteremia group,the proportion of malignancy (21/83 vs 12/119,x2 =8.2846,P ＜ 0.01 ),venous catheter ( 28/83 vs 3/119,x2 =36.67,P ＜ 0.01 ),diabetes ( 37/83 vs 0/119,x2 =68.226,P ＜0.05),surgical operation(37/83 vs 0/119,x2 =68.226,P ＜0.01),previous antibiotics(78/83 vs 10/119,x2 =173.5657,P ＜ 0.01 ) in nosocomial bacteremia group were higher.Multivariable logistic regression analysis showed that only 4 factors were significantly and independently responsible for nosocomial bacteremia,They were malignancy ( P ＜ 0.05,OR =3.186),diabetes ( P ＜0.001,OR =4.821 ),venous catheter( P ＜ 0.05,OR =2.135),previous antibiotics ( P ＜ 0.05,OR =2.135 ).The bacteria in nosocomial bacteremia group showed more ability to resist to antibiotics.Conclusions We should pay more attention to the patients with diabetes or malignancy or venous catheter or previous treated with antibiotics.These patients have more chances to develop to nosocomial bacteremia and infect by the drug-resistant bacteria.